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Labetalol is a drug used to treat high blood pressure.
It’s also known by its brand names Normodyne and Trandate.
This medicine is in a group of drugs called beta blockers.
It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.
Labetalol is also sometimes used to treat chest pain and to treat people with tetanus.
The drug comes in a tablet and intravenous (IV) form.
Labetalol controls high blood pressure, but it does not cure it.
You should continue to take labetalol even if you feel well.
The drug is only part of a complete treatment program for high blood pressure that may also include diet, exercise, and weight control.
The Food and Drug Administration approved labetalol in 1984; the drug is manufactured by Prometheus Laboratories.
Labetalol Warnings You should not stop taking labetalol without talking to your doctor first.
If this drug is stopped suddenly, it may cause chest pain or heart attack in some people.
This medication may also make you drowsy, so you should not drive a car or operate machinery until you know how it will affect you.
Your blood pressure should be checked regularly to evaluate your response to labetalol.
You should also check your pulse periodically.
If your pulse rate is faster or slower than it should be, call your doctor.
Before taking labetalol, you should tell your doctor and pharmacist if you: Are allergic to it or another other drugs Have ever had heart, kidney, or liver disease; asthma or other lung disease; severe allergies ; diabetes, or pheochromocytoma (an adrenal gland tumor) Are pregnant, plan to become pregnant, or are breastfeeding Are having surgery, including dental surgery Labetalol and Pregnancy It’s not known whether labetalol will harm an unborn baby, though the drug has been linked to heart and lung problems in newborns.
Labetalol can pass into breast milk and may harm a breastfeeding baby.
BasicDescription Back to Top Labetalol Side Effects Common Side Effects of Labetalol Some side effects of labetalol may include: Excessive tiredness Tingling scalp or skin Dizziness Lightheadedness Upset stomach Stuffy nose Fatigue Serious Side Effects of Labetalol If you experience any of the following symptoms, call your doctor immediately: Swelling of the lower legs and feet Sudden weight change Shortness of breath or wheezing Chest pain Severe slow heart rate Back to Top Labetalol Interactions Patients who take diabetes medications to lower blood sugar (such as insulin or oral antidiabetic drugs) may need to monitor their blood sugar more frequently while taking labetalol.
Halothane anesthesia may contribute to the blood-pressure lowering effects of labetalol.
Combining labetalol with tricyclic antidepressants such as amitriptyline (Elavil, Endep), imipramine (Tofranil), or nortriptyline (Pamelor) may lead to an increase in tremor.
If combined with adrenergic-stimulating drugs used for treating asthma, such as albuterol (Proventil, Ventolin) or pirbuterol (Maxair), the effects of labetalol may counteract the effects of the stimulating drugs and reduce their effectiveness.
Cimetidine (Tagamet) may increase the effectiveness of labetalol by blocking its elimination and increasing its levels in the blood.
Less labetalol may be needed when cimetidine and labetalol are used together.
You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs or supplements you are taking.
You can continue your normal diet and activities unless otherwise instructed by your doctor while taking labetalol.
However, consuming alcohol while on labetalol can make you drowsier.
Back to Top Labetalol Dosage The recommended starting oral dose of labetalol is 100 milligrams (mg), twice a day.
The dose can be increased by 100 mg twice daily, every two to three days based on your response.
Usual maintenance doses are 200-400 mg, twice daily.
People with very high blood pressure may require 1.2 to 2.4 grams daily.
The initial intravenous dose of the drug is 20 mg injected over two minutes.
Additional injections of 40 or 80 mg may be given every 10 minutes as needed up to a total dose of 300 mg.
The medicine may also be given by intravenous infusion at 1 to 2 milligrams/minute.
Labetalol Overdose If you suspect an overdose, you should contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Missed Dose of Labetalol If you miss a dose of labetalol, take it as soon as you remember.
However, if it is almost time for the next dose, skip the missed dose and continue to follow your regular dosing schedule.
Do not double up on doses.
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