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This inhibition decreases the expression of proinflammatory cytokines, such as IL-2. Cyclosporine A is a commercially available under the trade name NEORAL from Novartis.Methods of providing cyclosporine formulations with improved bioavailability are described in U.S. Patent Nos. 4,388,307, 6,468,968, 5,051,402, 5,342,625, 5,977,066, and 6,022,852.
Additional analysis of the importance of these morphologic subtypes was undertaken in the NIH FSGS Clinical Trials cohort of 138 patients with steroid-resistant primary FSGS. 17 The trial participants were randomly assigned to receive mycophenolate mofetil and dexamethasone versus cyclosporine, in addition to standard angiotensin-converting-enzyme (ACE) inhibitor or angiotensin-receptor blocker (ARB) therapy. A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission, Intern Med, 2011, vol. 50 (pg. 233 – 238 ) Google Scholar Crossref Search ADS PubMed 3 Vlassopoulos D, Divari E, Savva S, et al.
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