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Glyburide is the generic version of the brand-name drugs DiaBeta and Micronase.
It’s used along with diet and exercise to help control blood-sugar levels in people who have type 2 diabetes.
If you have type 2 diabetes, your body doesn’t make or use the hormone insulin normally, so it can’t control the amount of sugar, or glucose, in the blood.
Glyburide is in a class of drugs known as sulfonylureas, which stimulate the pancreas to produce the hormone insulin.
Insulin directs your body’s cells to store excess sugar, lowering the levels that circulate in your blood.
Taking glyburide, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes.
These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions.
The Food and Drug Administration (FDA) approved glyburide in 1984.
Glyburide Warnings You shouldn’t take glyburide if you have type 1 diabetes (the body doesn’t produce any insulin) or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is untreated).
Before taking this medicine, tell your doctor if you have or have ever had: G6PD deficiency (an inherited enzyme condition) Hemolytic anemia (a lack of red blood cells) Hormone disorders involving the pituitary, adrenal, or thyroid gland Heart, kidney, or liver disease A nerve disorder that affects bodily functions Alert your physician if you’ve taken chlorpropamide (Diabenese), another sulfonylurea drug for diabetes, in the past two weeks.
You shouldn’t take this medicine if you take bosentan (Tracleer), a drug used for high blood pressure in the lungs ( pulmonary arterial hypertension ), because it may increase your risk of liver problems.
Before having surgery, including a dental procedure, tell your doctor or dentist that you are taking glyburide.
Some diabetes drugs may increase your risk of serious heart problems.
However, blood sugars that are out of control can damage your heart, or other organs, too.
Talk to your doctor about these risks.
Tell your physician if you experience an illness, fever, injury, or unusual stress while taking glyburide, because these can change your blood sugar and the dosage you need.
Glyburide may cause changes in your blood sugar.
You should know the symptoms of high (hyperglycemic) or low ( hypoglycemic ) blood-sugar episodes and be prepared to treat them.
Your doctor will probably want to check your glucose levels often while you are taking glyburide.
Keep all healthcare appointments, including the ones for tests at a lab.
This medicine helps control blood-sugar levels, but it doesn’t cure diabetes.
Don’t stop taking glyburide without first talking to your doctor.
Always wear a diabetic ID bracelet to be sure you get proper treatment in case of an emergency.
Pregnancy and Glyburide Glyburide is a pregnancy category C drug, which means harm to an unborn baby can’t be ruled out.
Tell your physician if you are, or if you are planning, to become pregnant.
Your healthcare provider might want you to take insulin during pregnancy.
Don’t breastfeed while using this drug.
It’s not known whether glyburide passes into breast milk or could harm a breastfeeding baby.
Gestational Diabetes and Glyburide Glyburide is sometimes used to treat women with a form of diabetes that occurs during pregnancy (known as gestational diabetes).
However, some studies have found glyburide may not be as safe or as effective as injected insulin.
Other studies have shown women with gestational diabetes may need higher doses of glyburide.
Talk to your doctor about the potential risks and benefits of using this medicine to treat gestational diabetes.
BasicDescription Back to Top Glyburide Side Effects Common Side Effects of Glyburide Tell your doctor if any of the following side effects become severe or don’t go away: Heartburn Nausea Upper abdominal fullness Rash Muscle or joint pain Blurred vision Serious Side Effects of Glyburide Call your doctor immediately if you experience any of the following serious side effects: Dark urine Light-colored stools Yellowing of the eyes or skin ( jaundice ) Fever Sore throat Diarrhea If you have any of the following and can’t reach your doctor, you may need emergency medical help: Pain in the upper right portion of the stomach Confusion or slurred speech Severe weakness Unusual bleeding or bruising Swelling of the eyes, face, lips, tongue, or throat Back to Top Glyburide Interactions Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking, especially: Angiotensin-converting enzyme (ACE) inhibitors, such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril ( Altace ), and trandolapril (Mavik) Antibiotics known as quinolone or fluoroquinolone, such as cinoxacin (Cinobac), ciprofloxacin ( Cipro ), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin ( Levaquin ), lomefloxacin (Maxaquin), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), or trovafloxacin and alatrofloxacin combination (Trovan) Aspirin and other nonsteroidal anti-inflammatory medications ( NSAIDs ), such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) Asthma drugs Blood thinners, such as warfarin ( Coumadin ) Beta blockers, such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol ( Inderal ) Bosentan (Tracleer), for high blood pressure in the lungs ( pulmonary hypertension ) Calcium channel blockers, such as amlodipine ( Norvasc ), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil ( Calan, Isoptin, Verelan ) Chloramphenicol, an antibiotic Clarithromycin (Biaxin), an antibiotic Cold medicines Contraceptives, such as birth control pills, patches, rings, implants, and injections Cyclosporine (Neoral, Sandimmune), an immunosuppressant Diabetes and blood-sugar drugs, such as insulin and others Disopyramide (Norpace), a heart drug Fluconazole (Diflucan), for fungal infections Hormone replacement therapy Isoniazid (INH) MAOIs, such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) Mental illness medications, such as fluoxetine ( Prozac, Sarafem) and others Miconazole (Monistat), for yeast infections Nausea medicine Niacin, a type of vitamin B used for many conditions Oral steroids such as dexamethasone ( Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone) Phenytoin ( Dilantin ), a seizure medicine Probenecid (Benemid), for preventing gout or to treat some types of arthritis Rifampin, an antibiotic for tuberculosis Salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan’s, others), and salsalate (Argesic, Disalcid, Salgesic) Sulfa drugs, including antibiotics, such as co-trimoxazole ( Bactrim, Septra); and the arthritis drug sulfasalazine (Azulfidine) Thyroid medications Water pills ( diuretics ) If you take colesevelam ( Welchol ), a drug for lowering “bad” (LDL) cholesterol, don’t take it until four hours after you’ve taken glyburide.
Glyburide and Alcohol Avoid drinking alcohol while taking glyburide, as it can lower blood sugar and increase your risk of side effects.
Although rare, drinking alcoholic beverages while on glyburide can cause headache, flushing, nausea, vomiting, chest pain, weakness, blurred vision, sweating, choking, mental confusion, breathing difficulties, or anxiety.
Glyburide and Other Interactions Glyburide can make your skin more sensitive to sunlight.
Avoid unnecessary sun exposure and tanning beds.
Also, wear protective clothing and sunscreen when you are outdoors.
This medicine may also make you drowsy or dizzy.
Don’t drive or perform any activity that requires alertness until you’re sure you can do so safely.
Back to Top Glyburide Dosage Glyburide comes as a tablet and is typically taken by mouth with breakfast or the first meal of the day.
This medicine is usually taken once a day.
However, some people may take it twice a day.
Follow the directions carefully when taking glyburide.
Don’t take more or less of the drug than is prescribed.
Your doctor might start you on a low dose and gradually increase it if needed.
Glyburide Overdose If you suspect an overdose, you should contact a poison-control center or emergency room immediately.
You can reach a poison-control center at (800) 222-1222.
Missed Dose of Glyburide Ask your doctor what to do if you forget a dose of glyburide, and write down those instructions.
As a general rule, if you miss a dose, take it as soon as your remember.
However, if it’s almost time for your next dose, skip the missed dose and continue on your regular dosing schedule.
Don’t take extra medicine to make up for a missed dose.
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